This PKCb1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates, cell lysates or other biological fluids..
Applications
ELISA
Reactivity
Human
Sensitivity
0.06ng/mL
Detection Limit
0.156-10ng/mL
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Storage Instruction
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
serum, plasma, tissue homogenates, cell lysates or other biological fluids.
Additional Info
Tissue Specificity
Expressed in neurons (at protein level). Absent in astrocytes (at protein level). Expressed in all tissues examined with highest expression in brain, lung, pancreas, and placenta. Expressed in cutaneous T-cell lymphomas (CTCL).
Post Translational Modifications
Function
Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac. May also act as a transcriptional corepressor for KDM5C and EZH2. Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination. Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters. Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression. Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform. Suppresses breast cancer, and prostate cancer cell invasion and metastasis.
Protein Name
Mynd-Type Zinc Finger-Containing Chromatin Reader Zmynd8Cutaneous T-Cell Lymphoma-Associated Antigen Se14-3Ctcl-Associated Antigen Se14-3Protein Kinase C-Binding Protein 1Rack7Transcription Coregulator Zmynd8Zinc Finger Mynd Domain-Containing Protein 8
Database Links
Cellular Localisation
NucleusChromosomeCytoplasmSequestered In The Cytoplasm Through The Interaction With Dbn1Localizes To Sites Of Dna Damage In A Kat5-Dependent And Dna Poly (Adp-Ribose)-Dependent MannerOn ChromatinLocalizes To Demethylated RegionsActive PromotersAnd Transcription Start Sites
