SDS-PAGE gel of recombinant human PIR-B protein under reducing conditions stained with Coomassie blue

Human PIR-B protein (Recombinant) (His-Tag) (STJP017536)

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STJP017536
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Short Description :Recombinant-Human PIR-B-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 0.1M NaCl, 1mM DTT
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:PIR
Gene ID:8544
Uniprot ID:PIR_HUMAN
Accession Number:NP_001018119
Immunogen:Human
Immunogen Region:1-290aa
Immunogen Sequence: MGSSKKVTLS VLSREQSEGV GARVRRSIGR PELKNLDPFL LFDEFKGGRP GGFPDHPHRG FETVSYLLEG GSMAHEDFCG HTGKMNPGDL QWMTAGRGIL HAEMPCSEEP AHGLQLWVNL RSSEKMVEPQ YQELKSEEIP KPSKDGVTVA VISGEALGIK SKVYTRTPTL YLDFKLDPGA KHSQPIPKGW TSFIYTISGD VYIGPD
Tissue Specificity Highly expressed in a subset of melanomas. Detected at very low levels in most tissues (at protein level). Expressed in all tissues, with highest level of expression in heart and liver.
Function Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro).
Protein Name Pirin
Probable Quercetin 2 -3-Dioxygenase Pir
Probable Quercetinase
Database Links Reactome: R-HSA-8935690
Cellular Localisation Nucleus
Cytoplasm
Predominantly Localized In Dot-Like Subnuclear Structures
Cytoplasmic Localization Of Pir Seems To Positively Correlate With Melanoma Progression
Alternative Protein Names Pirin protein
Probable Quercetin 2 -3-Dioxygenase Pir protein
Probable Quercetinase protein
PIR protein

Information sourced from Uniprot.org

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