| Function | Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene.the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma. |
| Protein Name | Pinin140 Kda Nuclear And Cell Adhesion-Related PhosphoproteinDesmosome-Associated ProteinDomain-Rich Serine ProteinDrs ProteinDrspMelanoma Metastasis Clone A ProteinNuclear Protein Sdk3Sr-Like Protein |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | Nucleus SpeckleCell JunctionDesmosomeCell-Cell Contact AreaPredominantly Desmosome Of Intercellular Adherens JunctionNot A Nucleocytoplasmic Shuttling Protein |
| Alternative Protein Names | Pinin protein140 Kda Nuclear And Cell Adhesion-Related PhosphoproteinDesmosome-Associated Protein proteinDomain-Rich Serine Protein proteinDrs Protein proteinDrsp proteinMelanoma Metastasis Clone A Protein proteinNuclear Protein Sdk3 proteinSr-Like Protein proteinPNN proteinDRS proteinMEMA protein |
Information sourced from Uniprot.org
