Human PIN4 protein (Recombinant) (N-His) (STJP006230)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human PIN4-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | PIN4 |
| Gene ID | 5303 |
| Uniprot ID | PIN4_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser23-Arg130 |
Additional Info
| Post Translational Modifications | Phosphorylated. Isoform 1 phosphorylation occurs both in the nucleus and the cytoplasm. Isoform 1 phosphorylation at Ser-19 does not affect its PPIase activity but is required for nuclear localization, and the dephosphorylation is a prerequisite for the binding to DNA. The unphosphorylated isoform 1 associates with the pre-rRNP complexes in the nucleus. Isoform 2 is sumoylated with SUMO2 and SUMO3. |
| Function | Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA. Isoform 2 binds to double-stranded DNA. |
| Protein Name | Peptidyl-Prolyl Cis-Trans Isomerase Nima-Interacting 4Parvulin-14Par14Hpar14Parvulin-17Par17Hpar17Peptidyl-Prolyl Cis-Trans Isomerase Pin4Ppiase Pin4Peptidyl-Prolyl Cis/Trans Isomerase EpvhHepvhRotamase Pin4 |
| Database Links | |
| Cellular Localisation | Isoform 1: NucleusNucleolusCytoplasmCytoskeletonSpindleColocalizes In The Nucleolus During Interphase And On The Spindle Apparatus During Mitosis With Npm1Isoform 2: MitochondrionMitochondrion MatrixImported In A Time- And Membrane Potential-Dependent Manner To The Mitochondrial MatrixBut Without Concomitant Processing Of The ProteinDirected To Mitochondria By A Novel N-Terminal Domain That Functions As A Non-Cleavable Mitochondrial Targeting Peptide |
| Alternative Protein Names | Peptidyl-Prolyl Cis-Trans Isomerase Nima-Interacting 4 proteinParvulin-14 proteinPar14 proteinHpar14 proteinParvulin-17 proteinPar17 proteinHpar17 proteinPeptidyl-Prolyl Cis-Trans Isomerase Pin4 proteinPpiase Pin4 proteinPeptidyl-Prolyl Cis/Trans Isomerase Epvh proteinHepvh proteinRotamase Pin4 proteinPIN4 protein |
Information sourced from Uniprot.org