Human PICK1 protein (Recombinant) (N-His-SUMO & C-Strep) (STJP008122)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human PICK1-N-His-SUMO & C-Strep protein was developed from e.coli for the region N-His-SUMO & C-Strep. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | PICK1 |
| Gene ID | 9463 |
| Uniprot ID | PICK1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly15-Leu114 |
Additional Info
| Post Translational Modifications | Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors. Palmitoylation on Cys-413 is essential for long-term synaptic depression (LTD). |
| Function | Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex.the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. |
| Protein Name | Prkca-Binding ProteinProtein Interacting With C Kinase 1Protein Kinase C-Alpha-Binding Protein |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-416993 |
| Cellular Localisation | CytoplasmPerinuclear RegionMembranePeripheral Membrane ProteinLipid-AnchorPostsynaptic DensitySynapseSynaptosomeCytoskeletonAlso Membrane-AssociatedPresent At Excitatory Synapses |
| Alternative Protein Names | Prkca-Binding Protein proteinProtein Interacting With C Kinase 1 proteinProtein Kinase C-Alpha-Binding Protein proteinPICK1 proteinPRKCABP protein |
Information sourced from Uniprot.org