Human PICK1 protein (Recombinant) (His-Tag) (STJP019017)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human PICK1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) containing 30% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PICK1 |
| Gene ID | 9463 |
| Uniprot ID | PICK1_HUMAN |
| Accession Number | NP_001034673 |
| Immunogen | Human |
| Immunogen Region | 1-415aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors. Palmitoylation on Cys-413 is essential for long-term synaptic depression (LTD). |
| Function | Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex.the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. |
| Protein Name | Prkca-Binding ProteinProtein Interacting With C Kinase 1Protein Kinase C-Alpha-Binding Protein |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-416993 |
| Cellular Localisation | CytoplasmPerinuclear RegionMembranePeripheral Membrane ProteinLipid-AnchorPostsynaptic DensitySynapseSynaptosomeCytoskeletonAlso Membrane-AssociatedPresent At Excitatory Synapses |
| Alternative Protein Names | Prkca-Binding Protein proteinProtein Interacting With C Kinase 1 proteinProtein Kinase C-Alpha-Binding Protein proteinPICK1 proteinPRKCABP protein |
Information sourced from Uniprot.org