Human PEX19 protein (Recombinant) (His-Tag) (STJP017328)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human PEX19-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PEX19 |
| Gene ID | 5824 |
| Uniprot ID | PEX19_HUMAN |
| Accession Number | NP_002848.1 |
| Immunogen | Human |
| Immunogen Region | 1-296aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Ubiquitously expressed. Isoform 1 is strongly predominant in all tissues except in utero where isoform 2 is the main form. |
| Function | Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. |
| Protein Name | Peroxisomal Biogenesis Factor 1933 Kda Housekeeping ProteinPeroxin-19Peroxisomal Farnesylated Protein |
| Database Links | Reactome: R-HSA-1369062Reactome: R-HSA-9603798 |
| Cellular Localisation | CytoplasmPeroxisome MembraneLipid-AnchorCytoplasmic SideMainly CytoplasmicSome Fraction Membrane-Associated To The Outer Surface Of Peroxisomes |
| Alternative Protein Names | Peroxisomal Biogenesis Factor 19 protein33 Kda Housekeeping Protein proteinPeroxin-19 proteinPeroxisomal Farnesylated Protein proteinPEX19 proteinHK33 proteinPXF proteinOK proteinSW-cl.22 protein |
Information sourced from Uniprot.org