Human PELI2 protein (Recombinant) (His-Tag) (STJP018888)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human PELI2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PELI2 |
| Gene ID | 57161 |
| Uniprot ID | PELI2_HUMAN |
| Accession Number | NP_067078 |
| Immunogen | Human |
| Immunogen Region | 1-420aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | Phosphorylated by IRAK1 and IRAK4 enhancing its E3 ligase activity. |
| Function | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. |
| Protein Name | E3 Ubiquitin-Protein Ligase Pellino Homolog 2Pellino-2Ring-Type E3 Ubiquitin Transferase Pellino Homolog 2 |
| Database Links | Reactome: R-HSA-9020702Reactome: R-HSA-937039Reactome: R-HSA-975144 |
| Cellular Localisation | |
| Alternative Protein Names | E3 Ubiquitin-Protein Ligase Pellino Homolog 2 proteinPellino-2 proteinRing-Type E3 Ubiquitin Transferase Pellino Homolog 2 proteinPELI2 protein |
Information sourced from Uniprot.org