Human PDIA6 protein (Recombinant) (His-Tag) (STJP019202)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human PDIA6-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Enzyme Activity |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing, 50mM NaCl, 2mM DTT and 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Specific activity > 10 A650/cm/min/mg. Enzymatic activity was confirmed by measuring the aggregation of insulin in the presence of DTT. |
Target Information
| Gene Symbol | PDIA6 |
| Gene ID | 10130 |
| Uniprot ID | PDIA6_HUMAN |
| Accession Number | NP_005733 |
| Immunogen | Human |
| Immunogen Region | 20-440aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed in platelets (at protein level). |
| Function | May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin. |
| Protein Name | Protein Disulfide-Isomerase A6Endoplasmic Reticulum Protein 5Er Protein 5Erp5Protein Disulfide Isomerase P5Thioredoxin Domain-Containing Protein 7 |
| Database Links | Reactome: R-HSA-381038Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | Endoplasmic Reticulum LumenCell MembraneMelanosomeIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Protein Names | Protein Disulfide-Isomerase A6 proteinEndoplasmic Reticulum Protein 5 proteinEr Protein 5 proteinErp5 proteinProtein Disulfide Isomerase P5 proteinThioredoxin Domain-Containing Protein 7 proteinPDIA6 proteinERP5 proteinP5 proteinTXNDC7 protein |
Information sourced from Uniprot.org