Human PCBP2 protein (Recombinant) (N-His) (STJP008382)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human PCBP2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | PCBP2 |
| Gene ID | 5094 |
| Uniprot ID | PCBP2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asn11-Ser173 |
Additional Info
| Post Translational Modifications | Phosphorylated. The non-phosphorylated form(s) exhibited the strongest poly(rC)-binding activity. (Microbial infection) Proteolytically cleaved by picornavirus proteinase 3CD. |
| Function | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Also binds poly(rU). Acts as a negative regulator of antiviral signaling. Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation. Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated. Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing. (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation. Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. |
| Protein Name | Poly(Rc-Binding Protein 2Alpha-Cp2Heterogeneous Nuclear Ribonucleoprotein E2Hnrnp E2 |
| Database Links | Reactome: R-HSA-72163Reactome: R-HSA-72203Reactome: R-HSA-936440Reactome: R-HSA-9692916 |
| Cellular Localisation | NucleusCytoplasmLoosely Bound In The NucleusMay Shuttle Between The Nucleus And The Cytoplasm |
| Alternative Protein Names | Poly(Rc-Binding Protein 2 proteinAlpha-Cp2 proteinHeterogeneous Nuclear Ribonucleoprotein E2 proteinHnrnp E2 proteinPCBP2 protein |
Information sourced from Uniprot.org