Human PAPPA protein (Recombinant) (N-His) (STJP005301)

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STJP005301
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PAPPA-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PAPPA
Gene ID: 5069
Uniprot ID: PAPP1_HUMAN
Immunogen Region: Leu317-Pro532
Immunogen: Homo sapiens (Human)
Post Translational Modifications There appear to be no free sulfhydryl groups.
Function Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.
Protein Name Pappalysin-1
Insulin-Like Growth Factor-Dependent Igf-Binding Protein 4 Protease
Igf-Dependent Igfbp-4 Protease
Igfbp-4ase
Pregnancy-Associated Plasma Protein A
Papp-A
Database Links Reactome: R-HSA-381426
Cellular Localisation Secreted
Alternative Protein Names Pappalysin-1 protein
Insulin-Like Growth Factor-Dependent Igf-Binding Protein 4 Protease protein
Igf-Dependent Igfbp-4 Protease protein
Igfbp-4ase protein
Pregnancy-Associated Plasma Protein A protein
Papp-A protein
PAPPA protein

Information sourced from Uniprot.org

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