Human PAFAH1B3 protein (Recombinant) (His-Tag) (STJP017783)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human PAFAH1B3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PAFAH1B3 |
| Gene ID | 5050 |
| Uniprot ID | PA1B3_HUMAN |
| Accession Number | NP_001139411 |
| Immunogen | Human |
| Immunogen Region | 1-231aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | In the adult, expressed in brain, skeletal muscle, kidney, thymus, spleen, colon, testis, ovary and peripheral blood leukocytes. In the fetus, highest expression occurs in brain. |
| Function | Alpha1 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. Both alpha1/alpha1 homodimer (PAFAH1B3/PAFAH1B3 homodimer) and alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B2 heterodimer) hydrolyze 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA) more efficiently than PAF, but they have little hydrolytic activity towards 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE). Plays an important role during the development of brain. |
| Protein Name | Platelet-Activating Factor Acetylhydrolase Ib Subunit Alpha1Paf Acetylhydrolase 29 Kda SubunitPaf-Ah 29 Kda SubunitPaf-Ah Subunit GammaPafah Subunit Gamma |
| Database Links | Reactome: R-HSA-6811436 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Platelet-Activating Factor Acetylhydrolase Ib Subunit Alpha1 proteinPaf Acetylhydrolase 29 Kda Subunit proteinPaf-Ah 29 Kda Subunit proteinPaf-Ah Subunit Gamma proteinPafah Subunit Gamma proteinPAFAH1B3 proteinPAFAHG protein |
Information sourced from Uniprot.org