Human PAFAH1B2 protein (Recombinant) (N-His) (STJP016021)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human PAFAH1B2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | PAFAH1B2 |
| Gene ID | 5049 |
| Uniprot ID | PA1B2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Ala229 |
Additional Info
| Function | Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE. May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis. |
| Protein Name | Platelet-Activating Factor Acetylhydrolase Ib Subunit Alpha2Paf Acetylhydrolase 30 Kda SubunitPaf-Ah 30 Kda SubunitPaf-Ah Subunit BetaPafah Subunit Beta |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-6811436 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Platelet-Activating Factor Acetylhydrolase Ib Subunit Alpha2 proteinPaf Acetylhydrolase 30 Kda Subunit proteinPaf-Ah 30 Kda Subunit proteinPaf-Ah Subunit Beta proteinPafah Subunit Beta proteinPAFAH1B2 proteinPAFAHB protein |
Information sourced from Uniprot.org