Human PADI6 protein (Recombinant) (N-GST & C-His) (STJP016051)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human PADI6-N-GST & C-His protein was developed from e.coli for the region N-GST & C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | PADI6 |
| Gene ID | 353238 |
| Uniprot ID | PADI6_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Val2-Pro694 |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-10, possibly by RSK-type kinases, and Ser-446 creates binding sites for 14-3-3 proteins. |
| Function | Structural constituent of cytoplasmic lattices, which plays a key role in early embryonic development. Cytoplasmic lattices consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos. They are required to store maternal proteins critical for embryonic development, such as ribosomal proteins and proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation. In contrast to other members of the family, does not show protein-arginine deiminase activity due to its inability to bind Ca(2+). |
| Protein Name | Inactive Protein-Arginine Deiminase Type-6Peptidyl Arginine Deiminase-Like ProteinPeptidylarginine Deiminase ViHpadviProtein-Arginine Deiminase Type ViProtein-Arginine Deiminase Type-6 |
| Database Links | Reactome: R-HSA-3247509 |
| Cellular Localisation | CytoplasmCytoplasmic VesicleSecretory VesicleCortical GranuleNucleusCore Component Of Cytoplasmic Lattices In OocytesAlso Nuclear |
| Alternative Protein Names | Inactive Protein-Arginine Deiminase Type-6 proteinPeptidyl Arginine Deiminase-Like Protein proteinPeptidylarginine Deiminase Vi proteinHpadvi proteinProtein-Arginine Deiminase Type Vi proteinProtein-Arginine Deiminase Type-6 proteinPADI6 proteinPAD6 protein |
Information sourced from Uniprot.org