Human PACSIN2 protein (Recombinant) (N-GST & C-His) (STJP008817)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human PACSIN2-N-GST & C-His protein was developed from e.coli for the region N-GST & C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | PACSIN2 |
| Gene ID | 11252 |
| Uniprot ID | PACN2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser425-Gln486 |
Additional Info
| Post Translational Modifications | Phosphorylated by casein kinase 2 (CK2). Phosphorylation by PKC probably decreases the membrane binding and tubulation capacities of PACSIN2, thereby modulating the lifetime of caveolae. |
| Function | Regulates the morphogenesis and endocytosis of caveolae. Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. Essential for endothelial organization in sprouting angiogenesis, modulates CDH5-based junctions. Facilitates endothelial front-rear polarity during migration by recruiting EHD4 and MICALL1 to asymmetric adherens junctions between leader and follower cells. (Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer. Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes. Involved in lipid droplet formation, which is important for HCV virion assembly. |
| Protein Name | Protein Kinase C And Casein Kinase Substrate In Neurons Protein 2Syndapin-2Syndapin-IiSdpii |
| Database Links | Reactome: R-HSA-8856828 |
| Cellular Localisation | CytoplasmCytoskeletonCytoplasmic Vesicle MembranePeripheral Membrane ProteinCytoplasmic SideCell ProjectionRuffle MembraneEarly EndosomeRecycling Endosome MembraneCell MembraneMembraneCaveolaCell JunctionAdherens JunctionDetected At The Neck Of Flask-Shaped CaveolaeLocalization To Tubular Recycling Endosomes Probably Requires Interaction With Micall1 And Ehd1 |
| Alternative Protein Names | Protein Kinase C And Casein Kinase Substrate In Neurons Protein 2 proteinSyndapin-2 proteinSyndapin-Ii proteinSdpii proteinPACSIN2 protein |
Information sourced from Uniprot.org