Human PACSIN1 protein (Recombinant) (C-His) (STJP013746)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human PACSIN1-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Supplied as a 0.22 Mu m filtered solution in 20mM PB, 150mM NaCl, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | PACSIN1 |
| Gene ID | 29993 |
| Uniprot ID | PACN1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Ile444 |
Additional Info
| Post Translational Modifications | Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC). |
| Function | Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT.this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis.this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission. Binds to membranes via its F-BAR domain and mediates membrane tubulation. |
| Protein Name | Protein Kinase C And Casein Kinase Substrate In Neurons Protein 1Syndapin-1 |
| Database Links | Reactome: R-HSA-8856828 |
| Cellular Localisation | CytoplasmCell ProjectionSynapseSynaptosomeRuffle MembraneMembranePeripheral Membrane ProteinCytoplasmic Vesicle MembraneCytosolCell MembraneCytoplasmic SideColocalizes With Mapt In AxonsIn Primary Neuronal CulturesPresent At A High Level In Presynaptic Nerve Terminals And In The Cell BodyColocalizes With Dnm1 At Vesicular Structures In The Cell Body And NeuritesAssociates With Membranes Via Its F-Bar Domain |
| Alternative Protein Names | Protein Kinase C And Casein Kinase Substrate In Neurons Protein 1 proteinSyndapin-1 proteinPACSIN1 proteinKIAA1379 protein |
Information sourced from Uniprot.org