| Function | ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and with relatively high calcium permeability. Furthermore, CTP functions as a weak affinity agonist for P2RX1. Plays a role a role in urogenital, immune and cardiovascular function. Specifically, plays an important role in neurogenic contraction of smooth muscle of the vas deferens, and therefore is essential for normal male reproductive function. In addition, contributes to smooth muscle contractions of the urinary bladder. On platelets, contributes to platelet activation and aggregation and thereby, also to thrombosis. On neutrophils, it is involved in chemotaxis and in mitigating the activation of circulating cells. |
| Protein Name | P2x Purinoceptor 1P2x1Atp ReceptorPurinergic Receptor |
| Database Links | Reactome: R-HSA-139853Reactome: R-HSA-418346Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinDetected At Plasma Membrane Lipid Rafts |
| Alternative Protein Names | P2x Purinoceptor 1 proteinP2x1 proteinAtp Receptor proteinPurinergic Receptor proteinP2RX1 proteinP2X1 protein |
Information sourced from Uniprot.org
