Human p18INK4c/CDKN2C protein (Recombinant) (His-Tag) (STJP017500)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human p18INK4c/CDKN2C-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 10% Glycerol, 200mM NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CDKN2C |
| Gene ID | 1031 |
| Uniprot ID | CDN2C_HUMAN |
| Accession Number | NP_001253 |
| Immunogen | Human |
| Immunogen Region | 1-168aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSHMAEPWG NELASAAARG DLEQLTSLLQ NNVNVNAQNG FGRTALQVMK LGNPEIARRL LLRGANPDLK DRTGFAVIHD AARAGFLDTL QTLLEFQADV NIEDNEGNLP LHLAAKEGHL RVVEFLVKHT ASNVGHRNHK GDTACDLARL YGRNEVVSLM QANGAGGATN LQ |
Additional Info
| Tissue Specificity | Highest levels found in skeletal muscle. Also found in pancreas and heart. |
| Function | Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. |
| Protein Name | Cyclin-Dependent Kinase 4 Inhibitor CCyclin-Dependent Kinase 6 InhibitorP18-Ink4cP18-Ink6 |
| Database Links | Reactome: R-HSA-2559580Reactome: R-HSA-2559582Reactome: R-HSA-2559585Reactome: R-HSA-69231 |
| Cellular Localisation | |
| Alternative Protein Names | Cyclin-Dependent Kinase 4 Inhibitor C proteinCyclin-Dependent Kinase 6 Inhibitor proteinP18-Ink4c proteinP18-Ink6 proteinCDKN2C proteinCDKN6 protein |
Information sourced from Uniprot.org