Human P-Selectin/SELP/CD62P protein (Recombinant) (C-His&Avi) {Biotin} (STJP020212)
SPECIFICATIONS
HostHEK293 cells
ConjugationBiotin
ImmunogenBiotinylated Recombinant Human P-Selectin/SELP/CD62P Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Trp42-Ala771) of Human P-Selectin/SELP/CD62P fused with His tag and Avi tag at the C-terminus.
General Information
| Short Description | Recombinant-Human P-Selectin/SELP/CD62P-C-His&Avi protein was developed in hek293 cells using the region Trp42-Ala771. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Biotin |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization. Contact us for customized product form or formulation. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | SELP |
| Gene ID | 6403 |
| Uniprot ID | LYAM3_HUMAN |
| Immunogen | Biotinylated Recombinant Human P-Selectin/SELP/CD62P Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Trp42-Ala771) of Human P-Selectin/SELP/CD62P fused with His tag and Avi tag at the C-terminus. |
| Immunogen Region | Trp42-Ala771 |
Additional Info
| Tissue Specificity | Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface. |
| Function | Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG. Mediates cell-cell interactions and cell adhesion via the interaction with integrin alpha-IIb/beta3 (ITGA2B:ITGB3) and integrin alpha-V/beta-3 (ITGAV:ITGB3). |
| Protein Name | P-SelectinCd62 Antigen-Like Family Member PGranule Membrane Protein 140Gmp-140Leukocyte-Endothelial Cell Adhesion Molecule 3Lecam3Platelet Activation Dependent Granule-External Membrane ProteinPadgemCd Antigen Cd62p |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-202733 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | P-Selectin proteinCd62 Antigen-Like Family Member P proteinGranule Membrane Protein 140 proteinGmp-140 proteinLeukocyte-Endothelial Cell Adhesion Molecule 3 proteinLecam3 proteinPlatelet Activation Dependent Granule-External Membrane Protein proteinPadgem proteinCd Antigen Cd62p proteinSELP proteinGMRP proteinGRMP protein |
Information sourced from Uniprot.org