Human OTOF protein (Recombinant) (N-His) (STJP015842)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human OTOF-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | OTOF |
| Gene ID | 9381 |
| Uniprot ID | OTOF_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met244-Ala596 |
Additional Info
| Function | Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes. |
| Protein Name | OtoferlinFer-1-Like Protein 2 |
| Database Links | Reactome: R-HSA-9609523Reactome: R-HSA-9662360 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneSingle-Pass Type Ii Membrane ProteinBasolateral Cell MembraneEndoplasmic Reticulum MembraneGolgi Apparatus MembranePresynaptic Cell MembraneCell MembraneDetected At Basolateral Cell Membrane With Synaptic Vesicles Surrounding The Ribbon And At The Presynaptic Plasma Membrane In The Inner Hair Cells (Ihcs) At Postnatal Day 30 (P30)Colocalizes With Gpr25 And Rab8b In Inner Hair Cells |
| Alternative Protein Names | Otoferlin proteinFer-1-Like Protein 2 proteinOTOF proteinFER1L2 protein |
Information sourced from Uniprot.org