Human OPG (Tumor Necrosis Factor Receptor Superfamily Member 11b) Antibody Pair (STJAP00054)
General Information
| Short Description | This OPG antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Mouse/Goat |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Polyclonal |
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Protein A or G.Detection Purification: Antigen Affinity. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | TNFRSF11B |
| Gene ID | 4982 |
| Uniprot ID | TR11B_HUMAN |
| Immunogen | Capture immunogen: Recombinant Human OPG protein.Detection Immunogen: Recombinant Human OPG protein. |
Additional Info
| Post Translational Modifications | N-glycosylated. Contains sialic acid residues. The N-terminus is blocked. |
| Function | Acts as a decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 11bOsteoclastogenesis Inhibitory FactorOsteoprotegerin |
| Database Links | Reactome: R-HSA-5669034 |
| Cellular Localisation | Secreted |
| Alternative Antibody Pair Names | Tumor Necrosis Factor Receptor Superfamily Member 11b antibody pairOsteoclastogenesis Inhibitory Factor antibody pairOsteoprotegerin antibody pairTNFRSF11B antibody pairOCIF antibody pairOPG antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human OPG (Tumor Necrosis Factor Receptor Superfamily Member 11b) Antibody Pair (STJAP00054)
This antibody pair detects human OPG, also known as Tumor Necrosis Factor Receptor Superfamily Member 11b (UniProt O00300). Reactivity is confirmed for human samples only.
The capture antibody is an unconjugated mouse monoclonal antibody and the detection antibody is a biotin-conjugated goat polyclonal antibody. Both are supplied at 0.5 mg/mL in PBS containing 0.04% Proclin 300 and 50% glycerol at pH 7.4.
This antibody pair has been validated for use in ELISA. No other assay formats are specified for this product.
Both the capture and detection antibodies were raised against recombinant human OPG protein. The capture antibody was purified by Protein A or G, while the detection antibody was purified by antigen affinity.
Both components should be stored at -20°C for long-term storage. Freeze-thaw cycles should be avoided to maintain antibody integrity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.