| Post Translational Modifications | The intrachain disulfide-bonds prevent N-glycosylation at some sites. N-glycosylated. |
| Function | Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. (Microbial infection) May serve as a receptor for adhesin A variant 3 (nadA) of N.meningitidis. |
| Protein Name | Oxidized Low-Density Lipoprotein Receptor 1Ox-Ldl Receptor 1C-Type Lectin Domain Family 8 Member ALectin-Like Oxidized Ldl Receptor 1Lox-1Lectin-Like Oxldl Receptor 1Hlox-1Lectin-Type Oxidized Ldl Receptor 1 Cleaved Into - Oxidized Low-Density Lipoprotein Receptor 1 - Soluble Form |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneLipid-AnchorSingle-Pass Type Ii Membrane ProteinMembrane RaftSecretedA Secreted Form Also ExistsLocalization To Membrane Rafts Requires Palmitoylation |
| Alternative Protein Names | Oxidized Low-Density Lipoprotein Receptor 1 proteinOx-Ldl Receptor 1 proteinC-Type Lectin Domain Family 8 Member A proteinLectin-Like Oxidized Ldl Receptor 1 proteinLox-1 proteinLectin-Like Oxldl Receptor 1 proteinHlox-1 proteinLectin-Type Oxidized Ldl Receptor 1 Cleaved Into - Oxidized Low-Density Lipoprotein Receptor 1 - Soluble Form proteinOLR1 proteinCLEC8A proteinLOX1 protein |
Information sourced from Uniprot.org
