Human Olfactomedin-4 protein (Recombinant) (STJP001865)
SPECIFICATIONS
HostHEK293
ConjugationUnconjugated
ImmunogenOptimized DNA sequence encoding mature chain of human Olfactomedin-4 (OLFM4) (Asp 21-GLN510) including an C terminal His tag was expressed in HEK293 cells. NA
General Information
| Short Description | Recombinant-Human Olfactomedin-4-protein was developed from hek293. For use in research applications. |
| Host | HEK293 |
| Note | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers. |
| Formulation | Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose. |
| Storage Instruction | Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA |
Target Information
| Gene Symbol | OLFM4 |
| Gene ID | 10562 |
| Uniprot ID | OLFM4_HUMAN |
| Immunogen | Optimized DNA sequence encoding mature chain of human Olfactomedin-4 (OLFM4) (Asp 21-GLN510) including an C terminal His tag was expressed in HEK293 cells. NA |
| Immunogen Region | Asp 21-GLN510 |
Additional Info
| Tissue Specificity | Expressed during myeloid lineage development. Much higher expression in bone marrow neutrophils than in peripheral blood neutrophils (at protein level). Strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone marrow and stomach. Overexpressed in some pancreatic cancer tissues. |
| Post Translational Modifications | N-glycosylated. |
| Function | May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin. |
| Protein Name | Olfactomedin-4Olm4Antiapoptotic Protein Gw112G-Csf-Stimulated Clone 1 ProteinHgc-1Holfd |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | SecretedExtracellular SpaceMitochondrionSubcellular Location Is Not Clearly Defined: Has Been Shown To Be SecretedBut Also In The MitochondrionCytoplasm And Plasma Membrane And In The Nucleus |
| Alternative Protein Names | Olfactomedin-4 proteinOlm4 proteinAntiapoptotic Protein Gw112 proteinG-Csf-Stimulated Clone 1 Protein proteinHgc-1 proteinHolfd proteinOLFM4 proteinGW112 proteinUNQ362 proteinPRO698 protein |
Information sourced from Uniprot.org