Human OAS3 (2 NA, 5 Oligoadenylate Synthetase 3) Sandwich ELISA Kit (STJE0011153)
SPECIFICATIONS
General Information
| Short Description | This OAS3 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 2.27ng/mL |
| Detection Limit | 6.25-400ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 4.5 hrs |
Target Information
| Gene Symbol | OAS3 |
| Gene ID | 4940 |
| Uniprot ID | OAS3_HUMAN |
| Sample Type | serum, plasma, tissue homogenates or other biological fluids. |
Additional Info
| Tissue Specificity | Present at high level in placenta trophoblast. |
| Post Translational Modifications | |
| Function | Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV). |
| Protein Name | 2'-5'-Oligoadenylate Synthase 3(2-5'Oligo(A Synthase 32-5a Synthase 3P100 OasP100oas |
| Database Links | Reactome: R-HSA-877300Reactome: R-HSA-8983711Reactome: R-HSA-909733 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative ELISA Names | 2'-5'-Oligoadenylate Synthase 3 ELISA kit(2-5'Oligo(A Synthase 3 ELISA kit2-5a Synthase 3 ELISA kitP100 Oas ELISA kitP100oas ELISA kitOAS3 ELISA kitP ELISA kitOKcl.4 ELISA kit |
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Information sourced from Uniprot.org