Human NUP50 protein (Recombinant) (N-His) (STJP006190)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human NUP50-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | NUP50 |
| Gene ID | 10762 |
| Uniprot ID | NUP50_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asn37-Ala269 |
Additional Info
| Function | Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling. Interacts with regulatory proteins of cell cycle progression including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B. |
| Protein Name | Nuclear Pore Complex Protein Nup5050 Kda NucleoporinNuclear Pore-Associated Protein 60 Kda-LikeNucleoporin Nup50 |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-159227Reactome: R-HSA-159230Reactome: R-HSA-159231Reactome: R-HSA-159236Reactome: R-HSA-165054Reactome: R-HSA-168271Reactome: R-HSA-168276Reactome: R-HSA-168325Reactome: R-HSA-168333Reactome: R-HSA-170822Reactome: R-HSA-180746Reactome: R-HSA-180910Reactome: R-HSA-191859Reactome: R-HSA-3108214Reactome: R-HSA-3232142Reactome: R-HSA-3301854Reactome: R-HSA-3371453Reactome: R-HSA-4085377Reactome: R-HSA-4551638Reactome: R-HSA-4570464Reactome: R-HSA-4615885Reactome: R-HSA-5578749Reactome: R-HSA-5619107Reactome: R-HSA-6784531Reactome: R-HSA-9609690Reactome: R-HSA-9610379Reactome: R-HSA-9705671 |
| Cellular Localisation | NucleusNuclear Pore ComplexNucleus MembranePeripheral Membrane ProteinNucleoplasmic SideLocalizes To The Nucleoplasmic Fibrils Of The Nuclear Pore ComplexDissociates From The Npc Structure Early During Prophase Of MitosisAssociates With The Newly Formed Nuclear Membrane During TelophaseIn The TestisThe Localization Changes During Germ Cell Differentiation From The Nuclear Surface In Spermatocytes To The Whole Nucleus (Interior) In Spermatids And Back To The Nuclear Surface In Spermatozoa |
| Alternative Protein Names | Nuclear Pore Complex Protein Nup50 protein50 Kda Nucleoporin proteinNuclear Pore-Associated Protein 60 Kda-Like proteinNucleoporin Nup50 proteinNUP50 proteinNPAP60L proteinPRO1146 protein |
Information sourced from Uniprot.org