Human NUDT4/DIPP2 protein (Recombinant) (His-Tag) (STJP018207)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human NUDT4/DIPP2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol 0.1M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NUDT4 |
| Gene ID | 11163 |
| Uniprot ID | NUDT4_HUMAN |
| Accession Number | NP_061967.3 |
| Immunogen | Human |
| Immunogen Region | 1-180aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed in heart and, at lower level in skeletal muscle, pancreas and kidney. |
| Function | Cleaves the beta-phosphate from diphosphoinositol polyphosphates such as PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 (diphosphoinositol tetrakisphosphate) and PP2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Diadenosine polyphosphates, particularly Ap6A (P(1),P(6)-bis(5a-adenosyl) hexaphosphate) and Ap5A (P(1),P(5)-bis(5'-adenosyl) pentaphosphate) are downstream effectors of a signaling cascade that regulates cardiac KATP channels, can also be substrates, although with lower preference than the diphosphoinositol polyphosphates. Can also catalyze the hydrolysis of 5-phosphoribose 1-diphosphate, generating the glycolytic activator ribose 1,5-bisphosphate. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. |
| Protein Name | Diphosphoinositol Polyphosphate Phosphohydrolase 2Dipp-2Diadenosine 5' -5'''-P1 -P6-Hexaphosphate Hydrolase 2Nucleoside Diphosphate-Linked Moiety X Motif 4Nudix Motif 4 |
| Database Links | Reactome: R-HSA-1855167 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Diphosphoinositol Polyphosphate Phosphohydrolase 2 proteinDipp-2 proteinDiadenosine 5' -5'''-P1 -P6-Hexaphosphate Hydrolase 2 proteinNucleoside Diphosphate-Linked Moiety X Motif 4 proteinNudix Motif 4 proteinNUDT4 proteinDIPP2 proteinKIAA0487 proteinHDCMB47P protein |
Information sourced from Uniprot.org