Human NUDT3 protein (Recombinant) (N-His) (STJP010810)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human NUDT3-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | NUDT3 |
| Gene ID | 11165 |
| Uniprot ID | NUDT3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly16-Ser163 |
Additional Info
| Function | Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and PP2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphosphate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) and diadenosine 5',5'''- P1,P5-pentaphosphate (Ap5A) being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Acts as a decapping enzyme that modulates the stability of a subset of mRNAs implicated in cell motility. Hydrolyzes monomethylated capped RNA after both the alpha- and beta-phosphates generating m7GMP + ppRNA and m7GDP + pRNA. Can hydrolyze unmethylated capped RNAs. Divalent cations zinc, magnesium and manganese determine its substrate specificity. Exhibits diphosphoinositol polyphosphate phosphohydrolase in the presence of magnesium ions, diadenosine hexaphosphate hydrolase activity in the presence of manganese ions and endopolyphosphatase activity in the presence of zinc ions. Plays an important role in limiting DNA damage and maintaining cell survival upon oxidative stress via its endopolyphosphatase activity. |
| Protein Name | Diphosphoinositol Polyphosphate Phosphohydrolase 1Dipp-1Diadenosine Hexaphosphate HydrolaseAp6a HydrolaseEndopolyphosphataseNucleoside Diphosphate-Linked Moiety X Motif 3Nudix Motif 3M7gpppn-Mrna HydrolaseM7gpppx Diphosphatase |
| Database Links | Reactome: R-HSA-1855167 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Diphosphoinositol Polyphosphate Phosphohydrolase 1 proteinDipp-1 proteinDiadenosine Hexaphosphate Hydrolase proteinAp6a Hydrolase proteinEndopolyphosphatase proteinNucleoside Diphosphate-Linked Moiety X Motif 3 proteinNudix Motif 3 proteinM7gpppn-Mrna Hydrolase proteinM7gpppx Diphosphatase proteinNUDT3 proteinDIPP proteinDIPP1 protein |
Information sourced from Uniprot.org