Human NUDC protein (Recombinant) (His-Tag) (STJP019285)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human NUDC-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NUDC |
| Gene ID | 10726 |
| Uniprot ID | NUDC_HUMAN |
| Accession Number | AAH02399 |
| Immunogen | Human |
| Immunogen Region | 1-331aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMGGEQEE ERFDGMLLAM AQQHEGGVQE LVNTFFSFLR RKTDFFIGGE EGMAEKLITQ TFSHHNQLAQ KTRREKRARQ EAERREKAER AARLAKEAKS ETSGPQIKEL TDEEAERLQL EIDQKKDAEN HEAQLKNGSL DSPGKQDTEE DEEEDEKDKG KLKPNLGNGA DLPNYRWTQT LSELDLAVPF CVNFRLKGKD MVVDIQRR |
Additional Info
| Tissue Specificity | Ubiquitous. Highly expressed in fetal liver, kidney, lung and brain. Highly expressed in adult pancreas, kidney, skeletal muscle, liver, lung, placenta, prostate, brain and heart. |
| Post Translational Modifications | Reversibly phosphorylated on serine residues during the M phase of the cell cycle. Phosphorylation on Ser-274 and Ser-326 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Phosphorylated by PLK and other kinases. |
| Function | Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation. |
| Protein Name | Nuclear Migration Protein NudcNuclear Distribution Protein C Homolog |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-68877Reactome: R-HSA-9648025Reactome: R-HSA-9696270 |
| Cellular Localisation | CytoplasmCytoskeletonNucleusSpindleMidbodyIn A Filamentous Pattern Adjacent To The Nucleus Of Migrating Cerebellar Granule CellsColocalizes With Tubulin And Dynein And With The Microtubule Organizing CenterDistributed Throughout The Cytoplasm Of Non-Migrating CellsA Small Proportion Is NuclearIn A Punctate PatternLocalizes To The Mitotic Spindle In A Eml4-Dependent Manner |
| Alternative Protein Names | Nuclear Migration Protein Nudc proteinNuclear Distribution Protein C Homolog proteinNUDC protein |
Information sourced from Uniprot.org