Human NUAK2 protein (Recombinant) (N-His) (STJP016380)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human NUAK2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | NUAK2 |
| Gene ID | 81788 |
| Uniprot ID | NUAK2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Lys46-Gly306 |
Additional Info
| Function | Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway. |
| Protein Name | Nuak Family Snf1-Like Kinase 2Omphalocele Kinase 2Snf1/Amp Kinase-Related KinaseSnark |
| Database Links | |
| Cellular Localisation | |
| Alternative Protein Names | Nuak Family Snf1-Like Kinase 2 proteinOmphalocele Kinase 2 proteinSnf1/Amp Kinase-Related Kinase proteinSnark proteinNUAK2 proteinOMPHK2 proteinSNARK protein |
Information sourced from Uniprot.org