Human NTH1 protein (Recombinant) (His-Tag) (STJP017344)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human NTH1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 40% Glycerol, 0.15M NaCl, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NTHL1 |
| Gene ID | 4913 |
| Uniprot ID | NTH_HUMAN |
| Accession Number | NP_002519.1 |
| Immunogen | Human |
| Immunogen Region | 1-312aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Widely expressed with highest levels in heart and lowest levels in lung and liver. |
| Post Translational Modifications | Ubiquitinated by TRIM26.leading to proteasomal degradation. |
| Function | Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Also has 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption. |
| Protein Name | Endonuclease Iii-Like Protein 1Hnth1Bifunctional Dna N-Glycosylase/Dna-(Apurinic Or Apyrimidinic Site LyaseDna Glycosylase/Ap Lyase |
| Database Links | Reactome: R-HSA-110328Reactome: R-HSA-110329Reactome: R-HSA-110357Reactome: R-HSA-9630221Reactome: R-HSA-9630222 |
| Cellular Localisation | NucleusMitochondrion |
| Alternative Protein Names | Endonuclease Iii-Like Protein 1 proteinHnth1 proteinBifunctional Dna N-Glycosylase/Dna-(Apurinic Or Apyrimidinic Site Lyase proteinDna Glycosylase/Ap Lyase proteinNTHL1 proteinNTH1 proteinOCTS3 protein |
Information sourced from Uniprot.org