Human NTCP (Na+ Taurocholate Cotransporting Polypeptide) Sandwich ELISA Kit (STJE0011125)
SPECIFICATIONS
General Information
| Short Description | This NTCP Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates, cell lysates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 0.27ng/mL |
| Detection Limit | 0.781-50ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 4.5 hrs |
Target Information
| Gene Symbol | SLC10A1 |
| Gene ID | 6554 |
| Uniprot ID | NTCP_HUMAN |
| Sample Type | tissue homogenates, cell lysates or other biological fluids. |
Additional Info
| Tissue Specificity | Expressed in liver. Expressed in placental trophoblasts. |
| Post Translational Modifications | |
| Function | As a major transporter of conjugated bile salts from plasma into the hepatocyte, it plays a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins. It is strictly dependent on the extracellular presence of sodium. It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate. Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation. (Microbial infection) Acts as an entry receptor for hepatitis B virus (HBV). The recognition for human SLC10A1/NTCP is highly specific. |
| Protein Name | Hepatic Sodium/Bile Acid CotransporterCell Growth-Inhibiting Gene 29 ProteinNa(+/Bile Acid CotransporterNa(+/Taurocholate Transport ProteinSodium/Taurocholate Cotransporting PolypeptideNtcpSolute Carrier Family 10 Member 1Slc10a1 |
| Database Links | Reactome: R-HSA-159418 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative ELISA Names | Hepatic Sodium/Bile Acid Cotransporter ELISA kitCell Growth-Inhibiting Gene 29 Protein ELISA kitNa(+/Bile Acid Cotransporter ELISA kitNa(+/Taurocholate Transport Protein ELISA kitSodium/Taurocholate Cotransporting Polypeptide ELISA kitNtcp ELISA kitSolute Carrier Family 10 Member 1 ELISA kitSlc10a1 ELISA kitSLC10A1 ELISA kitNTCP ELISA kitGIG29 ELISA kit |
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Information sourced from Uniprot.org