Human NRG2 protein (Recombinant) (N-His) (STJP010433)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human NRG2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | NRG2 |
| Gene ID | 9542 |
| Uniprot ID | NRG2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser114-Asn374 |
Additional Info
| Post Translational Modifications | Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. Extensive glycosylation precedes the proteolytic cleavage. |
| Function | Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor. |
| Protein Name | Pro-Neuregulin-2 - Membrane-Bound IsoformPro-Nrg2 Cleaved Into - Neuregulin-2Nrg-2Divergent Of Neuregulin-1Don-1Neural- And Thymus-Derived Activator For Erbb KinasesNtak |
| Database Links | Reactome: R-HSA-1227986Reactome: R-HSA-1236394Reactome: R-HSA-1250196Reactome: R-HSA-1250342Reactome: R-HSA-1250347Reactome: R-HSA-1251985Reactome: R-HSA-1257604Reactome: R-HSA-1306955Reactome: R-HSA-1358803Reactome: R-HSA-1963640Reactome: R-HSA-1963642Reactome: R-HSA-2219530Reactome: R-HSA-5673001Reactome: R-HSA-6785631Reactome: R-HSA-6811558Reactome: R-HSA-8847993Reactome: R-HSA-8863795Reactome: R-HSA-9664565Reactome: R-HSA-9665686 |
| Cellular Localisation | Pro-Neuregulin-2Membrane-Bound Isoform: Cell MembraneSingle-Pass Type I Membrane ProteinDoes Not Seem To Be ActiveNeuregulin-2: Secreted |
| Alternative Protein Names | Pro-Neuregulin-2 - Membrane-Bound Isoform proteinPro-Nrg2 Cleaved Into - Neuregulin-2 proteinNrg-2 proteinDivergent Of Neuregulin-1 proteinDon-1 proteinNeural- And Thymus-Derived Activator For Erbb Kinases proteinNtak proteinNRG2 proteinNTAK protein |
Information sourced from Uniprot.org