Human NR3C2 protein (Recombinant) (N-GST) (STJP003829)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human NR3C2-N-GST protein was developed from e.coli for the region N-GST. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | NR3C2 |
| Gene ID | 4306 |
| Uniprot ID | MCR_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly789-Lys984 |
Additional Info
| Post Translational Modifications | Phosphorylated. |
| Function | Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. |
| Protein Name | Mineralocorticoid ReceptorMrNuclear Receptor Subfamily 3 Group C Member 2 |
| Database Links | Reactome: R-HSA-3371497Reactome: R-HSA-383280Reactome: R-HSA-4090294 |
| Cellular Localisation | CytoplasmNucleusEndoplasmic Reticulum MembranePeripheral Membrane ProteinCytoplasmic And Nuclear In The Absence Of LigandNuclear After Ligand-BindingWhen Bound To Hsd11b2It Is Found Associated With The Endoplasmic Reticulum Membrane |
| Alternative Protein Names | Mineralocorticoid Receptor proteinMr proteinNuclear Receptor Subfamily 3 Group C Member 2 proteinNR3C2 proteinMCR proteinMLR protein |
Information sourced from Uniprot.org