Human NPC2 protein (Recombinant) (N-His) (STJP007968)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human NPC2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | NPC2 |
| Gene ID | 10577 |
| Uniprot ID | NPC2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asp31-Leu151 |
Additional Info
| Function | Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport. |
| Protein Name | Npc Intracellular Cholesterol Transporter 2Epididymal Secretory Protein E1Human Epididymis-Specific Protein 1He1Niemann-Pick Disease Type C2 Protein |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-8964038 |
| Cellular Localisation | SecretedEndoplasmic ReticulumLysosomeInteraction With Cell-Surface M6pr Mediates Endocytosis And Targeting To Lysosomes |
| Alternative Protein Names | Npc Intracellular Cholesterol Transporter 2 proteinEpididymal Secretory Protein E1 proteinHuman Epididymis-Specific Protein 1 proteinHe1 proteinNiemann-Pick Disease Type C2 Protein proteinNPC2 proteinHE1 protein |
Information sourced from Uniprot.org