Human NOX4 protein (Recombinant) (N-His) (STJP006053)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human NOX4-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | NOX4 |
| Gene ID | 50507 |
| Uniprot ID | NOX4_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly210-Glu424 |
Additional Info
| Post Translational Modifications | Deubiquitinated by USP19. Isoform 4: N-glycosylated and glycosylation is required for its proper function. Isoform 3: N-glycosylated. |
| Function | NADPH oxidase that catalyzes predominantly the reduction of oxygen to H2O2. Can also catalyze to a smaller extent, the reduction of oxygen to superoxide. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Promotes ferroptosis, reactive oxygen species production and reduced glutathione (GSH) levels by activating NLRP3 inflammasome activation and cytokine release. Isoform 4: NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. Involved in redox signaling in vascular cells. Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage. Isoform 3: Lacks superoxide-generating NADPH oxidase activity. |
| Protein Name | Nadph Oxidase 4Kidney Oxidase-1Kox-1Kidney Superoxide-Producing Nadph OxidaseRenal Nad(Ph-Oxidase |
| Database Links | Reactome: R-HSA-3299685Reactome: R-HSA-9702518Reactome: R-HSA-9703465 |
| Cellular Localisation | CytoplasmEndoplasmic Reticulum MembraneMulti-Pass Membrane ProteinCell MembraneCell JunctionFocal AdhesionNucleusIsoform 4: NucleusNucleolusPerinuclear RegionIsoform 3: CytoplasmIsoform 5: CytoplasmIsoform 6: Cytoplasm |
| Alternative Protein Names | Nadph Oxidase 4 proteinKidney Oxidase-1 proteinKox-1 proteinKidney Superoxide-Producing Nadph Oxidase proteinRenal Nad(Ph-Oxidase proteinNOX4 proteinRENOX protein |
Information sourced from Uniprot.org