Human NOSIP protein (Recombinant) (N-His) (STJP006254)

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STJP006254
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human NOSIP-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: NOSIP
Gene ID: 51070
Uniprot ID: NOSIP_HUMAN
Immunogen Region: Gly62-Ser295
Immunogen: Homo sapiens (Human)
Function E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB. Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.
Protein Name Nitric Oxide Synthase-Interacting Protein
E3 Ubiquitin-Protein Ligase Nosip
Ring-Type E3 Ubiquitin Transferase Nosip
Enos-Interacting Protein
Database Links Reactome: R-HSA-203754
Cellular Localisation Cytoplasm
Nucleus
Translocates From Nucleus To Cytoplasm In The G2 Phase Of The Cell Cycle
Alternative Protein Names Nitric Oxide Synthase-Interacting Protein protein
E3 Ubiquitin-Protein Ligase Nosip protein
Ring-Type E3 Ubiquitin Transferase Nosip protein
Enos-Interacting Protein protein
NOSIP protein
CGI-25 protein

Information sourced from Uniprot.org

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