Human NOSIP (Nitric Oxide Synthase Interacting Protein) Sandwich ELISA Kit (STJE0011016)
SPECIFICATIONS
General Information
| Short Description | This NOSIP Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 0.053ng/mL |
| Detection Limit | 0.156-10ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 4.5 hrs |
Target Information
| Gene Symbol | NOSIP |
| Gene ID | 51070 |
| Uniprot ID | NOSIP_HUMAN |
| Sample Type | tissue homogenates or other biological fluids. |
Additional Info
| Tissue Specificity | Expressed in heart, brain and lung. Present in endothelial cells (at protein level). |
| Post Translational Modifications | |
| Function | E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB. Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity. |
| Protein Name | Nitric Oxide Synthase-Interacting ProteinE3 Ubiquitin-Protein Ligase NosipRing-Type E3 Ubiquitin Transferase NosipEnos-Interacting Protein |
| Database Links | Reactome: R-HSA-203754 |
| Cellular Localisation | CytoplasmNucleusTranslocates From Nucleus To Cytoplasm In The G2 Phase Of The Cell Cycle |
| Alternative ELISA Names | Nitric Oxide Synthase-Interacting Protein ELISA kitE3 Ubiquitin-Protein Ligase Nosip ELISA kitRing-Type E3 Ubiquitin Transferase Nosip ELISA kitEnos-Interacting Protein ELISA kitNOSIP ELISA kitCGI-25 ELISA kit |
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Information sourced from Uniprot.org