Human NMRAL1 protein (Recombinant) (His-Tag) (STJP017696)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human NMRAL1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 0.15M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NMRAL1 |
| Gene ID | 57407 |
| Uniprot ID | NMRL1_HUMAN |
| Accession Number | NP_065728 |
| Immunogen | Human |
| Immunogen Region | 1-299aa |
| Immunogen Sequence |
Additional Info
| Function | Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer. |
| Protein Name | Nmra-Like Family Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-70635 |
| Cellular Localisation | CytoplasmPerinuclear RegionNucleusUnder Normal Redox Growth Conditions Localizes In The Cytoplasm And Perinuclear RegionNuclear Localization Is Promoted By Increased Intracellular Nitric Oxide And Reduced Nadph/Nadp(+) Ratios |
| Alternative Protein Names | Nmra-Like Family Domain-Containing Protein 1 proteinNMRAL1 proteinHSCARG protein |
Information sourced from Uniprot.org