Human NMNAT3 protein (Recombinant) (N-His) (STJP015204)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human NMNAT3-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | NMNAT3 |
| Gene ID | 349565 |
| Uniprot ID | NMNA3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Ser252 |
Additional Info
| Function | Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form.nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. May be involved in the maintenance of axonal integrity. Also functions as a stress-response chaperone protein that prevents toxic aggregation of proteins.this function may be independent of its NAD(+) synthesis activity. |
| Protein Name | Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 3Nmn/Namn Adenylyltransferase 3Nicotinamide-Nucleotide Adenylyltransferase 3Nmn Adenylyltransferase 3Nicotinate-Nucleotide Adenylyltransferase 3Namn Adenylyltransferase 3Pyridine Nucleotide Adenylyltransferase 3Pnat-3 |
| Database Links | Reactome: R-HSA-196807 |
| Cellular Localisation | Mitochondrion |
| Alternative Protein Names | Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 3 proteinNmn/Namn Adenylyltransferase 3 proteinNicotinamide-Nucleotide Adenylyltransferase 3 proteinNmn Adenylyltransferase 3 proteinNicotinate-Nucleotide Adenylyltransferase 3 proteinNamn Adenylyltransferase 3 proteinPyridine Nucleotide Adenylyltransferase 3 proteinPnat-3 proteinNMNAT3 proteinFKSG76 protein |
Information sourced from Uniprot.org