Human NLGN3 protein (Recombinant-Active) (C-His) (STJP012295)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human NLGN3-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA. When recombinant human NLGN3 is Immobilised at 2 Mu g/mL, biotinylated recombinant human Neurexin 1 beta binds with a typical ED50 = 150-900 ng/mL. |
Target Information
| Gene Symbol | NLGN3 |
| Gene ID | 54413 |
| Uniprot ID | NLGN3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ala39-Ser709 (Ser92Tyr) |
Additional Info
| Function | Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system. |
| Protein Name | Neuroligin-3Gliotactin Homolog |
| Database Links | Reactome: R-HSA-6794361 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinSynapseDetected At Both Glutamatergic And Gabaergic Synapses |
| Alternative Protein Names | Neuroligin-3 proteinGliotactin Homolog proteinNLGN3 proteinKIAA1480 proteinNL3 protein |
Information sourced from Uniprot.org