Human NKG2-D/KLRK1/CD314 protein (Recombinant) (N-raFc) (STJP001522)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human NKG2-D/KLRK1/CD314 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ile73-Val216) of human NKG2-D/KLRK1/CD314 (Accession #NP_031386.2) fused with a raFc tag at the N-terminus.
General Information
| Short Description | Recombinant-Human NKG2-D/KLRK1/CD314-N-raFc protein was developed in hek293 cells using the region Ile73-Val216. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA. Immobilized human MICA at 2 Mu g/mL (100 Mu L/well) can bind NKG2D with a linear range of 0.61-205.43 ng/mL. |
| Determination Method | <0.1 EU/Mu g |
Target Information
| Gene Symbol | KLRK1 |
| Gene ID | 22914 |
| Uniprot ID | NKG2D_HUMAN |
| Immunogen | Recombinant Human NKG2-D/KLRK1/CD314 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ile73-Val216) of human NKG2-D/KLRK1/CD314 (Accession #NP_031386.2) fused with a raFc tag at the N-terminus. |
| Immunogen Region | Ile73-Val216 |
| Immunogen Sequence | IWSAVFLNSLFNQEVQIPLT ESYCGPCPKNWICYKNNCYQ FFDESKNWYESQASCMSQNA SLLKVYSKEDQDLLKLVKSY HWMGLVHIPTNGSWQWEDGS ILSPNLLTIIEMQKGDCALY ASSFKGYIENCSTPNTYIC MQRTV |
Additional Info
| Function | Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. |
| Protein Name | Nkg2-D Type Ii Integral Membrane ProteinKiller Cell Lectin-Like Receptor Subfamily K Member 1Nk Cell Receptor DNkg2-D-Activating Nk ReceptorCd Antigen Cd314 |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-2172127Reactome: R-HSA-2424491 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinColocalized With Hcst On The Cell Surface |
| Alternative Protein Names | Nkg2-D Type Ii Integral Membrane Protein proteinKiller Cell Lectin-Like Receptor Subfamily K Member 1 proteinNk Cell Receptor D proteinNkg2-D-Activating Nk Receptor proteinCd Antigen Cd314 proteinKLRK1 proteinD12S2489E proteinNKG2D protein |
Information sourced from Uniprot.org