Human NHP2L1 protein (Recombinant) (His-Tag) (STJP016951)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human NHP2L1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 7.5) containing 100mM NaCl, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SNU13 |
| Gene ID | 4809 |
| Uniprot ID | NH2L1_HUMAN |
| Accession Number | NP_004999 |
| Immunogen | Human |
| Immunogen Region | 1-128aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSHMTEADV NPKAYPLADA HLTKKLLDLV QQSCNYKQLR KGANEATKTL NRGISEFIVM AADAEPLEII LHLPLLCEDK NVPYVFVRSK QALGRACGVS RPVIACSVTI KEGSQLKQQI QSIQQSIERL LV |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Function | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs). |
| Protein Name | Nhp2-Like Protein 1High Mobility Group-Like Nuclear Protein 2 Homolog 1Otk27Snu13 HomologHsnu13U4/U6.U5 Small Nuclear Ribonucleoprotein Snu13U4/U6.U5 Tri-Snrnp 15.5 Kda Protein Cleaved Into - Nhp2-Like Protein 1 - N-Terminally Processed |
| Database Links | Reactome: R-HSA-6790901Reactome: R-HSA-6791226Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusNucleolusConcentrated In The Dense Fibrillar Component Of The Nucleolus |
| Alternative Protein Names | Nhp2-Like Protein 1 proteinHigh Mobility Group-Like Nuclear Protein 2 Homolog 1 proteinOtk27 proteinSnu13 Homolog proteinHsnu13 proteinU4/U6.U5 Small Nuclear Ribonucleoprotein Snu13 proteinU4/U6.U5 Tri-Snrnp 15.5 Kda Protein Cleaved Into - Nhp2-Like Protein 1 - N-Terminally Processed proteinSNU13 proteinNHP2L1 protein |
Information sourced from Uniprot.org