Human NHP2 protein (Recombinant) (N-His) (STJP014820)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human NHP2-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Supplied as a 0.22 Mu m filtered solution in 20mM Tris-HCl, 100mM NaCl, 1mM DTT, pH 8.0. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | NHP2 |
| Gene ID | 55651 |
| Uniprot ID | NHP2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Leu153 |
Additional Info
| Function | Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. |
| Protein Name | H/Aca Ribonucleoprotein Complex Subunit 2Nucleolar Protein Family A Member 2Snornp Protein Nhp2 |
| Database Links | Reactome: R-HSA-171319Reactome: R-HSA-6790901 |
| Cellular Localisation | NucleusNucleolusCajal BodyAlso Localized To Cajal Bodies (Coiled Bodies) |
| Alternative Protein Names | H/Aca Ribonucleoprotein Complex Subunit 2 proteinNucleolar Protein Family A Member 2 proteinSnornp Protein Nhp2 proteinNHP2 proteinNOLA2 proteinHSPC286 protein |
Information sourced from Uniprot.org