Human NHP2 protein (Recombinant) (His-Tag) (STJP017003)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human NHP2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 0.1M NaCl, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NHP2 |
| Gene ID | 55651 |
| Uniprot ID | NHP2_HUMAN |
| Accession Number | NP_060308 |
| Immunogen | Human |
| Immunogen Region | 1-153aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MTKIKADPDG PEAQAEACSG ERTYQELLVN QNPIAQPLAS RRLTRKLYKC IKKAVKQKQI RRGVKEVQKF VNKGEKGIMV LAGDTLPIEV YCHLPVMCED RNLPYVYIPS KTDLGAAAGS KRPTCVIMVK PHEEYQEAYD ECLEEVQSLP LPL |
Additional Info
| Tissue Specificity | Expressed in brain, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus. Also expressed at lower levels in the liver. |
| Function | Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. |
| Protein Name | H/Aca Ribonucleoprotein Complex Subunit 2Nucleolar Protein Family A Member 2Snornp Protein Nhp2 |
| Database Links | Reactome: R-HSA-171319Reactome: R-HSA-6790901 |
| Cellular Localisation | NucleusNucleolusCajal BodyAlso Localized To Cajal Bodies (Coiled Bodies) |
| Alternative Protein Names | H/Aca Ribonucleoprotein Complex Subunit 2 proteinNucleolar Protein Family A Member 2 proteinSnornp Protein Nhp2 proteinNHP2 proteinNOLA2 proteinHSPC286 protein |
Information sourced from Uniprot.org