Human Neutrophil Elastase (Neutrophil Elastase) Antibody Pair (STJAP00897)

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STJAP00897-2
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Short Description :This Neutrophil Elastase antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the.
Applications:ELISA
Host:Rabbit/Rabbit
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal/Monoclonal
Clone ID :R03-1S-2/R06-4K-2
Isotype:IgG
Conjugation:Unconjugated
Purification:Affinity Purification
Dilution Range:Determined by end user
Formulation:0.01M PBS, pH 7.2
Storage Instruction:Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol:ELANE
Gene ID:1991
Uniprot ID:ELNE_HUMAN
Immunogen:Recombinant protein
Tissue Specificity Bone marrow cells. Neutrophil.
Function Serine protease that modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. Promotes cleavage of GSDMB, thereby inhibiting pyroptosis. Promotes blood coagulation. Through the activation of the platelet fibrinogen receptor integrin alpha-IIb/beta-3, potentiates platelet aggregation induced by a threshold concentration of cathepsin G (CTSG). Cleaves and thus inactivates tissue factor pathway inhibitor (TFPI). Capable of killing E.coli but not S.aureus in vitro.digests outer membrane protein A (ompA) in E.coli and K.pneumoniae.
Protein Name Neutrophil Elastase
Bone Marrow Serine Protease
Elastase-2
Human Leukocyte Elastase
Hle
Medullasin
Pmn Elastase
Database Links Reactome: R-HSA-1442490
Reactome: R-HSA-1474228
Reactome: R-HSA-1592389
Reactome: R-HSA-5620971
Reactome: R-HSA-6798695
Reactome: R-HSA-6803157
Reactome: R-HSA-977606
Reactome: R-HSA-9911233
Cellular Localisation Cytoplasmic Vesicle
Phagosome
Localized In Phagolysosomes Following Ingestion Of E
Coli By Neutrophils
Alternative Antibody Pair Names Neutrophil Elastase antibody pair
Bone Marrow Serine Protease antibody pair
Elastase-2 antibody pair
Human Leukocyte Elastase antibody pair
Hle antibody pair
Medullasin antibody pair
Pmn Elastase antibody pair
ELANE antibody pair
ELA2 antibody pair

Information sourced from Uniprot.org

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