Human Neurogranin (Neurogranin) Antibody Pair (STJAP00800)
General Information
| Short Description | This Neurogranin antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the. |
| Applications | ELISA |
| Host | Rabbit/Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Clone ID | R18-3A-4/R55-1L-5 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | Determined by end user |
| Formulation | 0.01M PBS, pH 7.2 |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | NRGN |
| Gene ID | 4900 |
| Uniprot ID | NEUG_HUMAN |
| Immunogen | Recombinant protein |
Additional Info
| Tissue Specificity | In the cerebral cortex, found in the cell bodies of neurons in layers II-VI, and in apical and basal dendrites of pyramidal neurons. Is not found in the dendrites in patients with Alzheimer disease. |
| Post Translational Modifications | Phosphorylated at Ser-36 by PHK and PKC, phosphorylation prevents interaction with Calmodulin and interrupts several learning- and memory-associated functions. |
| Function | Acts as a 'third messenger' substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium. |
| Protein Name | NeurograninNgRc3 Cleaved Into - Neug(55-78 |
| Database Links | Reactome: R-HSA-9620244 |
| Cellular Localisation | |
| Alternative Antibody Pair Names | Neurogranin antibody pairNg antibody pairRc3 Cleaved Into - Neug(55-78 antibody pairNRGN antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human Neurogranin (Neurogranin) Antibody Pair (STJAP00800)
This antibody pair detects human Neurogranin (UniProt Q92686) and has confirmed reactivity against the human protein only. No cross-reactivity data for other species is provided.
Both antibodies are rabbit monoclonal IgGs (clone IDs R18-3A-4 and R55-1L-5), supplied unconjugated at 1 mg/mL in 0.01M PBS, pH 7.2, and purified by affinity chromatography. Neither antibody carries a conjugate or tag, so end users are responsible for labeling the detection antibody as required.
This pair is validated for use in ELISA. No other assay formats are listed for STJAP00800.
Optimal working concentrations are determined by the end user and are not predefined in the product specifications. Titration experiments are recommended to establish the appropriate concentrations for each antibody within the specific assay setup.
Both antibodies should be stored at 4°C for short-term use. For long-term storage, aliquot and store at -20°C. Repeated freeze/thaw cycles should be avoided to maintain activity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.