Human NEU1/Sialidase-1 protein (Recombinant) (N-His) (STJP005885)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human NEU1/Sialidase-1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | NEU1 |
| Gene ID | 4758 |
| Uniprot ID | NEUR1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ala110-Pro262 |
Additional Info
| Post Translational Modifications | N-glycosylated. Phosphorylation of tyrosine within the internalization signal results in inhibition of sialidase internalization and blockage on the plasma membrane. |
| Function | Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. |
| Protein Name | Sialidase-1Acetylneuraminyl HydrolaseG9 SialidaseLysosomal SialidaseN-Acetyl-Alpha-Neuraminidase 1 |
| Database Links | Reactome: R-HSA-4085001Reactome: R-HSA-4341670Reactome: R-HSA-6798695Reactome: R-HSA-9840310 |
| Cellular Localisation | Lysosome MembranePeripheral Membrane ProteinLumenal SideLysosome LumenCell MembraneCytoplasmic VesicleLysosomeLocalized Not Only On The Inner Side Of The Lysosomal Membrane And In The Lysosomal LumenBut Also On The Plasma Membrane And In Intracellular Vesicles |
| Alternative Protein Names | Sialidase-1 proteinAcetylneuraminyl Hydrolase proteinG9 Sialidase proteinLysosomal Sialidase proteinN-Acetyl-Alpha-Neuraminidase 1 proteinNEU1 proteinNANH protein |
Information sourced from Uniprot.org