Human NEIL2 protein (Recombinant) (His-Tag) (STJP017639)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human NEIL2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% Glycerol, 0.1M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NEIL2 |
| Gene ID | 252969 |
| Uniprot ID | NEIL2_HUMAN |
| Accession Number | NP_659480 |
| Immunogen | Human |
| Immunogen Region | 1-332aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSHMPEGPL VRKFHHLVSP FVGQQVVKTG GSSKKLQPAS LQSLWLQDTQ VHGKKLFLRF DLDEEMGPPG SSPTPEPPQK EVQKEGAADP KQVGEPSGQK TLDGSSRSAE LVPQGEDDSE YLERDAPAGD AGRWLRVSFG LFGSVWVNDF SRAKKANKRG DWRDPSPRLV LHFGGGGFLA FYNCQLSWSS SPVVTPTCDI LSEKFHRG |
Additional Info
| Tissue Specificity | Detected in testis, skeletal muscle, heart, brain, placenta, lung, pancreas, kidney and liver. |
| Function | Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. |
| Protein Name | Endonuclease 8-Like 2Dna Glycosylase/Ap Lyase Neil2Dna-(Apurinic Or Apyrimidinic Site Lyase Neil2Endonuclease Viii-Like 2Nei Homolog 2Neh2Nei-Like Protein 2 |
| Database Links | Reactome: R-HSA-110328Reactome: R-HSA-110329Reactome: R-HSA-5649702 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Endonuclease 8-Like 2 proteinDna Glycosylase/Ap Lyase Neil2 proteinDna-(Apurinic Or Apyrimidinic Site Lyase Neil2 proteinEndonuclease Viii-Like 2 proteinNei Homolog 2 proteinNeh2 proteinNei-Like Protein 2 proteinNEIL2 protein |
Information sourced from Uniprot.org