Human NEIL1 protein (Recombinant) (N-His) (STJP005839)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human NEIL1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | NEIL1 |
| Gene ID | 79661 |
| Uniprot ID | NEIL1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser43-Ala314 |
Additional Info
| Function | Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. |
| Protein Name | Endonuclease 8-Like 1Dna Glycosylase/Ap Lyase Neil1Dna-(Apurinic Or Apyrimidinic Site Lyase Neil1Endonuclease Viii-Like 1Fpg1Nei Homolog 1Neh1Nei-Like Protein 1 |
| Database Links | Reactome: R-HSA-110328Reactome: R-HSA-110329Reactome: R-HSA-5649702Reactome: R-HSA-9616334 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeNucleusChromosomeDuring MitosisAssociates With Centrosomes And Condensed Chromatin |
| Alternative Protein Names | Endonuclease 8-Like 1 proteinDna Glycosylase/Ap Lyase Neil1 proteinDna-(Apurinic Or Apyrimidinic Site Lyase Neil1 proteinEndonuclease Viii-Like 1 proteinFpg1 proteinNei Homolog 1 proteinNeh1 proteinNei-Like Protein 1 proteinNEIL1 protein |
Information sourced from Uniprot.org