Human NEIL1 (Nei Endonuclease VIII Like Protein 1) Sandwich ELISA Kit Ready-To-Use Kit (STJE0017297)
SPECIFICATIONS
General Information
| Short Description | This NEIL1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 0.062ng/mL |
| Detection Limit | 0.156-10ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 3 hrs |
Target Information
| Gene Symbol | NEIL1 |
| Gene ID | 79661 |
| Uniprot ID | NEIL1_HUMAN |
| Immunogen Region | Ready-To-Use |
| Sample Type | tissue homogenates or other biological fluids. |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | |
| Function | Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. |
| Protein Name | Endonuclease 8-Like 1Dna Glycosylase/Ap Lyase Neil1Dna-(Apurinic Or Apyrimidinic Site Lyase Neil1Endonuclease Viii-Like 1Fpg1Nei Homolog 1Neh1Nei-Like Protein 1 |
| Database Links | Reactome: R-HSA-110328Reactome: R-HSA-110329Reactome: R-HSA-5649702Reactome: R-HSA-9616334 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeNucleusChromosomeDuring MitosisAssociates With Centrosomes And Condensed Chromatin |
| Alternative ELISA Names | Endonuclease 8-Like 1 ELISA kitDna Glycosylase/Ap Lyase Neil1 ELISA kitDna-(Apurinic Or Apyrimidinic Site Lyase Neil1 ELISA kitEndonuclease Viii-Like 1 ELISA kitFpg1 ELISA kitNei Homolog 1 ELISA kitNeh1 ELISA kitNei-Like Protein 1 ELISA kitNEIL1 ELISA kit |
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Information sourced from Uniprot.org